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| Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
28/11/2018 |
Actualizado : |
28/11/2018 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
SALINAS, L.M.; BALSEIRO, A.; JIRÓN, W.; PERALTA, A.; MUÑÓZ, D.; FAJARDO, J.; GAYO, E.; MARTÍNEZ, I.Z.; RIET-CORREA, F.; GARDNER, D.R.; GARCÍA MARÍN, J.F. |
Afiliación : |
LUIS MANUEL SALINAS, Universidad Internacional Antonio de Valdivieso (UNIAV), Rivas, Nicaragua; Facultad de Veterinaria, Universidad de León, Campus de Vegazana, León, Spain.; ANA BALSEIRO, Servicio Regional de Investigación y Desarrollo Agroalimentario (SERIDA), Centro de Biotecnología Animal, Gijón, Asturias, Spain.; WILLIAM JIRÓN, Universidad Nacional Autónoma de Nicaragua (UNAN), León, Nicaragua.; ANA PERALTA, Universidad Nacional Autónoma de Nicaragua (UNAN), León, Nicaragua.; DAVID MUÑÓZ, Universidad Nacional Autónoma de Nicaragua (UNAN), León, Nicaragua.; JORGE FAJARDO, Universidad Nacional Autónoma de Nicaragua (UNAN), León, Nicaragua.; ELENA GAYO, Facultad de Veterinaria, Universidad de León, Campus de Vegazana, León, Spain.; ILEANA ZORHAYA MARTÍNEZ, Facultad de Veterinaria, Universidad de León, Campus de Vegazana, León, Spain; Universidad Popular Autónoma del Estado de Puebla (UPAEP), Mexico.; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; DALE R. GARDNER, Poisonous Plant Research Laboratory, Logan, UT, United States.; JUAN FRANCISCO GARCÍA MARÍN, Facultad de Veterinaria, Universidad de León, Campus de Vegazana, León, Spain. |
Título : |
Neurological syndrome in goats associated with Ipomoea trifida and Ipomoea carnea containing calystegines. |
Fecha de publicación : |
2018 |
Fuente / Imprenta : |
Toxicon, January 2019, Volume 157, Pages 8-11. |
ISSN : |
0041-0101 |
DOI : |
10.1016/j.toxicon.2018.11.291 |
Idioma : |
Inglés |
Notas : |
Article history: Received 16 September 2018 // Received in revised form 7 November 2018 // Accepted 9 November 2018 // Available online 14 November 2018.
This work was partially supported by a grant from Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria ( INIA , Spain), reference number E-RTA2013-00013-C04-04 (FEDER co-funded). |
Contenido : |
ABSTRACT.
A disease characterized by ataxia, tremors and nystagmus had been observed in goats in Nicaragua. The main histologic lesions were loss and neuronal vacuolation of Purkinje cells and Wallerian-like degeneration mainly in the cerebellum, suggesting a glycoprotein storage disease. Ipomoea carnea and Ipomoea trifida found in the paddocks were negative for swainsonine, but contained calystegines at 0.02% and 0.06% suggesting that the disease was caused by these substances, which are competitive inhibitors of β-glucosidase and α-galactosidase activities.
© 2018 Elsevier Ltd |
Palabras claves : |
CALYSTEGINES; GOAT; IPOMOEA CARNEA; IPOMOEA TRIFIDA; NICARAGUA; POISONING. |
Asunto categoría : |
-- |
Marc : |
LEADER 01903naa a2200349 a 4500 001 1059313 005 2018-11-28 008 2018 bl uuuu u00u1 u #d 022 $a0041-0101 024 7 $a10.1016/j.toxicon.2018.11.291$2DOI 100 1 $aSALINAS, L.M. 245 $aNeurological syndrome in goats associated with Ipomoea trifida and Ipomoea carnea containing calystegines.$h[electronic resource] 260 $c2018 500 $aArticle history: Received 16 September 2018 // Received in revised form 7 November 2018 // Accepted 9 November 2018 // Available online 14 November 2018. This work was partially supported by a grant from Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria ( INIA , Spain), reference number E-RTA2013-00013-C04-04 (FEDER co-funded). 520 $aABSTRACT. A disease characterized by ataxia, tremors and nystagmus had been observed in goats in Nicaragua. The main histologic lesions were loss and neuronal vacuolation of Purkinje cells and Wallerian-like degeneration mainly in the cerebellum, suggesting a glycoprotein storage disease. Ipomoea carnea and Ipomoea trifida found in the paddocks were negative for swainsonine, but contained calystegines at 0.02% and 0.06% suggesting that the disease was caused by these substances, which are competitive inhibitors of β-glucosidase and α-galactosidase activities. © 2018 Elsevier Ltd 653 $aCALYSTEGINES 653 $aGOAT 653 $aIPOMOEA CARNEA 653 $aIPOMOEA TRIFIDA 653 $aNICARAGUA 653 $aPOISONING 700 1 $aBALSEIRO, A. 700 1 $aJIRÓN, W. 700 1 $aPERALTA, A. 700 1 $aMUÑÓZ, D. 700 1 $aFAJARDO, J. 700 1 $aGAYO, E. 700 1 $aMARTÍNEZ, I.Z. 700 1 $aRIET-CORREA, F. 700 1 $aGARDNER, D.R. 700 1 $aGARCÍA MARÍN, J.F. 773 $tToxicon, January 2019, Volume 157, Pages 8-11.
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| Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha actual : |
30/06/2023 |
Actualizado : |
30/06/2023 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Circulación / Nivel : |
Internacional - -- |
Autor : |
GIANNITTI, F.; GARCÍA, J. P.; ADAMS, V.; ARMENDANO, J.; BEINGESSER, J.; ROOD, J.; UZAL, F. A. |
Afiliación : |
FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JORGE P. GARCÍA, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; VICKI ADAMS, Monash University, Parkville, Victoria, Australia; JOAQUÍN I. ARMENDANO, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; JULIANN BEINGESSER, California Animal Health and Food Safety Laboratoy, University of California at Davis, San Bernardino, CA; JULIAN I. ROOD, Monash University, Parkville, Victoria, Australia; FRANCISCO A. UZAL, Monash University, Parkville, Victoria, Australia. |
Título : |
Experimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions. |
Complemento del título : |
Infectious Disease - Original Article. |
Fecha de publicación : |
2023 |
Fuente / Imprenta : |
Veterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669 |
ISSN : |
0300-9858 (print); 1544-2217 (online). |
DOI : |
10.1177/03009858231171669 |
Idioma : |
Inglés |
Notas : |
Article history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). -- |
Contenido : |
ABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023 MenosABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 ... Presentar Todo |
Palabras claves : |
Clostridium perfringens type D; Enterotoxemia; ETX; Experimental infection; Kidneys; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Renal pathology; Sheep. |
Asunto categoría : |
L10 Genética y mejoramiento animal |
Marc : |
LEADER 03352naa a2200325 a 4500 001 1064216 005 2023-06-30 008 2023 bl uuuu u00u1 u #d 022 $a0300-9858 (print); 1544-2217 (online). 024 7 $a10.1177/03009858231171669$2DOI 100 1 $aGIANNITTI, F. 245 $aExperimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions.$h[electronic resource] 260 $c2023 500 $aArticle history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). -- 520 $aABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023 653 $aClostridium perfringens type D 653 $aEnterotoxemia 653 $aETX 653 $aExperimental infection 653 $aKidneys 653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA 653 $aRenal pathology 653 $aSheep 700 1 $aGARCÍA, J. P. 700 1 $aADAMS, V. 700 1 $aARMENDANO, J. 700 1 $aBEINGESSER, J. 700 1 $aROOD, J. 700 1 $aUZAL, F. A. 773 $tVeterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669
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